This issue of the ECDC Communicable Disease Threats Report (CDTR) covers the period 4 – 10 December 2022 and includes updates on COVID-19, Ebola virus, respiratory syncytial virus, streptococcal infection, diphtheria, seasonal influenza, mpox (monkeypox), hepatitis, MERS-CoV, meningitis, and mass gathering monitoring at the FIFA World Cup 2022 Qatar.