This issue of the ECDC Communicable Disease Threats Report (CDTR) covers the period 30 November – 6 December2024 and includes updates on increases in respiratory infections due to Mycoplasma pnemoniae in the EU/EEA, SARS-CoV-2 variant classification, Influenza A(H5N1), Avian influenza, Middle East respiratory syndrome, an unknown disease in the Democratic Republic of the Congo, mpox, suspected viral hemorrhagic fever in Sierra Leone, and overview of respiratory virus epidemiology in the EU/EEA.