This issue of the ECDC Communicable Disease Threats Report (CDTR) covers the period 20 – 26 July and includes updates on Avian influenza A(H5N6), SARS-CoV-2 variant classification, Overview of respiratory virus epidemiology in the EU/EEA, Circulating vaccine-derived poliovirus type 2 (cVDPV2), cholera, Crimean-Congo haemorrhagic fever, Oropouche virus disease, Seasonal surveillance of West Nile virus infections, Mass gathering monitoring – Olympic and Paralympic Games, Nipah virus disease.