This issue of the ECDC Communicable Disease Threats Report (CDTR) covers the period 14-20 December 2024 and includes updates on Cyclone Chido, Mpox due to monkeypox virus clade I and II, SARS-CoV-2 variant classification, Overview of respiratory virus epidemiology in the EU/EEA, Marburg virus disease and Avian influenza A(H5N1).