This issue of the ECDC Communicable Disease Threats Report (CDTR) covers the period 11 – 17 January 2025 and includes updates on respiratory virus epidemiology in the EU/EEA, mpox, influenza, cholera, Marburg virus, rabies, and chikungunya, measles, polio, MRSA, and mass gathering monitoring for the Jubilee of 2025 in Italy.